Article

Multi-domain AD risk burden and plasma biomarkers in cognitively unimpaired adults

2026-06-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Alzheimer’s disease (AD) pathology accumulates decades before symptom onset, yet how the cumulative effect of genetic, familial, and modifiable lifestyle risk burden jointly affects plasma biomarker levels and trajectories in cognitively unimpaired older adults remains unknown. <h4>Methods</h4> We analyzed data from 261 participants in the PREVENT-AD cohort. A composite r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ce4b1fa-0a89-557e-9aea-753b82bed2f9
DOI: 10.64898/2026.06.11.26355499

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-domain AD risk burden and plasma biomarkers in cognitively unimpaired adultsDOI 10.64898/2026.06.11.26355499Read

Orthogonal Contributions of Genetic, Clinical, and Social Determinants of Health Risk Burdens on Alzheimer’s Disease PathophysiologySemantic proximity Read

Plasma biomarker levels and cognitive decline in a heterogenous community-based cohort with multiple comorbiditiesSemantic proximity Read

A/T/N polygenic risk score for cognitive decline in old ageSemantic proximity Read

Polygenic Scores of Core-1 Alzheimer’s Disease Biomarkers Predict Early Cognitive and Pathological ChangeSemantic proximity Read

Effect of Pathway-specific Polygenic Risk Scores for Alzheimer’s Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic IndividualsSemantic proximity Read

Plasma biomarker trajectories: Impact of AD genetic risk and clinical progressionSemantic proximity Read

Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults.Semantic proximity Read

Novel Plasma Proteins Associated With Alzheimer’s Disease Risk in APOE ε4 Carriers and Non-carriersSemantic proximity Read

Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK BiobankSemantic proximity Read

The Role of Genomic-Informed Risk Assessments in Predicting Dementia OutcomesSemantic proximity Read

Lifestyle, genetic risk, plasma pTau217, and incident cognitive impairment in WRAP.Semantic proximity Read

Relationship between BrainAge Polygenetic Risk Score and plasma biomarkers in the A4/LEARN studiesSemantic proximity Read