Back to search

Article

The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization

2019-12-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> Alzheimer’s disease is the leading cause of disability and healthy life years lost. However, to date, there are no proven causal and modifiable risk factors, or effective interventions. <h4>Objective</h4> We aimed to identify: a) factors modified by prodromal Alzheimer’s disease pathophysiology and b) causal risk factors for Alzheimer’s disease. We identified factors modified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
70a3ecab-1003-56f9-bec0-74bfc2ab93db
DOI
10.1101/2019.12.18.19013847
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomizationDOI 10.1101/2019.12.18.19013847
The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization.Semantic proximity
Causal associations between potentially modifiable risk factors and the Alzheimer’s disease phenome: A Mendelian randomization studySemantic proximity
Genetic Associations Between Modifiable Risk Factors and Alzheimer DiseaseSemantic proximity
Systematic evaluation of multifactorial causal associations for Alzheimer's disease and an interactive platform based on Mendelian randomization analysis——MRADSemantic proximity
Medical risk factors, ApoE haplotype, and Alzheimer’s disease: a large-scale analysisSemantic proximity
Causal insights of modifiable cardiovascular risk factors for dementia risk - potential for efficient prevention and improved brain health.Semantic proximity
Systematic evaluation of multifactorial causal associations for Alzheimer's disease and an interactive platform MRAD developed based on Mendelian randomization analysis.Semantic proximity
Alzheimer's disease polygenic risk's association with all-cause dementia through the plasma metabolome in the UK Biobank study.Semantic proximity
A Phenome-wide Association and Mendelian Randomization Study for Alzheimer's Disease: A Prospective Cohort Study of 502,493 Participants From the UK Biobank.Semantic proximity
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis.Semantic proximity
Alzheimer's Disease Investigated via Gene-Environment Interactions, Biochemical Pathways, Cellular Processes, and Disease Phenotype VariabilitySemantic proximity
Five Major Psychiatric Disorders and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.Semantic proximity
Select a neighboring publication to make it the new centre.