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Sex-specific early cognitive changes are linked to global and pathway-specific genetic risk for Alzheimer's disease in at-risk individuals.

Biology of sex differences - 17 Feb 2026

Genius Patricia, Fernández-Bonet Alba, Rodríguez-Fernández Blanca, Gallay Clara, Gonzalez-Escalante Armand, Sánchez-Benavides Gonzalo, López-Martos David, Esteller Manel, Navarro Arcadi, Gispert Juan D, Brugulat-Serrat Anna, Vilor-Tejedor Natalia

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative condition in which genetic predisposition plays a key role, yet the sex-specific mechanisms linking genetic risk to early cognitive changes remain unclear. This study examined the impact of polygenic risk scores (PRS) on early cognitive changes in 318 cognitively unimpaired participants from the ALFA+ cohort, a nested longitudinal cohort from the ALFA...

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Identifiers

PMID: 41703636
DOI: 10.1186/s13293-025-00800-w
PMCID: PMC13014877

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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