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Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes

2023-02-24

Abstract excerpt

Adoptive immunotherapy with Tregs is a promising approach for prevention or treatment of type 1 diabetes. Islet antigen-specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical application. To generate Tregs that recognize islet antigens, we engineered a chimeric antigen receptor (CAR) derived from a monoclonal antibody with specificity for the in...

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Literature Corpus work
b74bf85b-394d-5db7-8e2d-2012ec94a2b1
DOI
10.1101/2023.02.23.529737
Open publication

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Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetesDOI 10.1101/2023.02.23.529737
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