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Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice.

Diabetes - 1 May 2012

Fousteri Georgia, Jasinski Jean, Dave Amy, Nakayama Maki, Pagni Philippe, Lambolez Florence, Juntti Therese, Sarikonda Ghanashyam, Cheng Yang, Croft Michael, Cheroutre Hilde, Eisenbarth George, von Herrath Matthias

Abstract excerpt

In diabetic patients and susceptible mice, insulin is a targeted autoantigen. Insulin B chain 9-23 (B:9-23) autoreactive CD4 T cells are key for initiating autoimmune diabetes in NOD mice; however, little is known regarding their origin and function. To this end, B:9-23-specific, BDC12-4.1 T-cell receptor (TCR) transgenic (Tg) mice were studied, of which, despite expressing a single TCR on the recombination...

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PMID: 22403296
DOI: 10.2337/db11-0671
PMCID: PMC3331775

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Source receipt: pubmed, retrieved 7 Sept 2026.

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