Article

Activation of T cell checkpoint pathways during β-cell antigen presentation by engineered dendritic cells promotes protection of non-obese diabetic mice from type 1 diabetes

2021-08-08

Abstract excerpt

Defective immune regulation has been recognized in type 1 diabetes (T1D). Immune regulatory T cell check-point receptors, which are generally upregulated on activated T cells, have been the molecules of attention as therapeutic targets for enhancing immune response in tumor therapy. We reported that dendritic cells (DCs) that are engineered to express selective ligands for checkpoint receptors can induce effective...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4bda4612-6eb8-5101-8c86-9e573f751c40
DOI: 10.1101/2021.08.08.455575

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of T cell checkpoint pathways during β-cell antigen presentation by engineered dendritic cells promotes protection of non-obese diabetic mice from type 1 diabetesDOI 10.1101/2021.08.08.455575Read

Altered Function of Antigen-Presenting Cells in Type 1 Diabetes: A Challenge for Antigen-Specific Immunotherapy?Semantic proximity Read

Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune checkpoint ligands can suppress autoimmune responses in type 1 diabetesSemantic proximity Read

Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.Semantic proximity Read

The Role of T Cell Receptor Signaling in the Development of Type 1 DiabetesSemantic proximity Read

Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s PrintSemantic proximity Read

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic DiseasesSemantic proximity Read

Induction of Tolerogenic Dendritic Cells by a PEGylated TLR7 Ligand for Treatment of Type 1 Diabetes.Semantic proximity Read

Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.Semantic proximity Read

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.Semantic proximity Read

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 DiabetesSemantic proximity Read

Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand.Semantic proximity Read

Natural Killer Cells as Key Mediators in Type I Diabetes ImmunopathologySemantic proximity Read