Article
I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1999
Noorchashm H, Lieu Y K, Noorchashm N, Rostami S Y, Greeley S A, Schlachterman A, Song H K, Noto L E, Jevnikar A M, Barker C F, Naji A
Abstract excerpt
B cell-deficient nonobese diabetic (NOD) mice are protected from the development of spontaneous autoimmune diabetes, suggesting a requisite role for Ag presentation by B lymphocytes for the activation of a diabetogenic T cell repertoire. This study specifically examines the importance of B cell-mediated MHC class II Ag presentation as a regulator of peripheral T cell tolerance to islet beta cells. We describe the...
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