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Article

Protective regulatory T cell generation in autoimmune diabetes by DNA covaccination with islet antigens and a selective CTLA-4 ligand.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Oct 2006

Glinka Yelena, Chang Yigang, Prud'homme Gérald J

Abstract excerpt

DNA vaccination of autoimmune diabetes-prone NOD mice with unmodified target islet antigens, i.e., preproinsulin (PPIns) or glutamic acid decarboxylase 65 (GAD65), is poorly protective. However, in this study, we demonstrate protection against disease by covaccination with a mutant B7-1 molecule (B7-1wa) that binds the negative T cell regulator CTLA-4 (CD152), but not CD28. Codelivery of plasmids encoding a...

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Share to Adoptive Transfer
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Islets of Langerhans

Share to Mice, Inbred NOD

Share to Receptors, Interleukin-2

Share to T-Lymphocytes, Regulatory

Share to Vaccines, DNA

Source

Identifiers

PMID: 16790365
DOI: 10.1016/j.ymthe.2006.03.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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