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Article

Treatment of T1D via optimized expansion of antigen-specific Tregs induced by IL-2/anti-IL-2 monoclonal antibody complexes and peptide/MHC tetramers.

Scientific reports - 25 May 2018

Izquierdo Cristina, Ortiz Angela Zarama, Presa Maximiliano, Malo Sara, Montoya Anna, Garabatos Nahir, Mora Conchi, Verdaguer Joan, Stratmann Thomas

Abstract excerpt

Type 1 diabetes can be overcome by regulatory T cells (Treg) in NOD mice yet an efficient method to generate and maintain antigen-specific Treg is difficult to come by. Here, we devised a combination therapy of peptide/MHC tetramers and IL-2/anti-IL-2 monoclonal antibody complexes to generate antigen-specific Treg and maintain them over extended time periods. We first optimized treatment protocols conceived to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29802270
DOI: 10.1038/s41598-018-26161-6
PMCID: PMC5970271

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