Article

Fourth generation CAR Tregs with <i>PDCD1</i> -driven IL-10 have enhanced suppressive function

2024-10-03

Abstract excerpt

<h4>ABSTRACT</h4> The potency of regulatory T cell (Treg) therapy has been transformed through use of chimeric antigen receptors (CAR). However, to date, CAR Treg therapy has not achieved long-lasting tolerance in mouse models, suggesting that additional engineering is required to unlock the full potential of these cells. We previously found that human Tregs produce minimal amounts of IL-10 and have a limited cap...

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Literature Corpus work: d2395576-20cf-59a2-855b-96ff3a7df4a8
DOI: 10.1101/2024.10.01.616177

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