Article

CD38 defines a therapeutically targetable pathogenic T cell population for precision immunotherapy in autoimmune diabetes

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes (T1D) is caused by T cell-mediated autoimmune destruction of insulin-producing islet β-cells. Treatment with T-cell depleting therapies delays the progression of stage 2 and 3 T1D, but these agents exert broad immunosuppressive effects on T cell populations, including T regulatory cells (Tregs), which are key in promoting immune tolerance. We evaluated non-obese diabetic (NOD) mi...

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Literature Corpus work: 36275934-c6a0-5558-b5e3-43ebd2c94150
DOI: 10.64898/2026.06.27.734105

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