Epigenetic mechanisms regulating CD8+ T cell senescence in aging humans

Abstract excerpt

<h4>ABSTRACT</h4> Aging leads to the decline of immunity, rendering the elderly susceptible to infection and disease. In the CD8+ T cell compartment, aging leads to a substantial increase of cells with high levels of senescence-associated ß-galactosidase activity (SA-ßGal) and other senescence characteristics, including a pro-inflammatory transcriptome and impaired proliferative potential. Using senescent cell is...

Topics

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• Cytomegalovirus and herpesvirus research
• Epigenetics and DNA Methylation
• FOXO transcription factor regulation
• Genetics, Aging, and Longevity in Model Organisms
• Genomics and Chromatin Dynamics
• Single-cell and spatial transcriptomics
• T-cell and B-cell Immunology
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

b7187c6b-7072-5b51-916d-521b5f9ebfbe

DOI

10.1101/2025.01.17.633634