Back to search

Article

Senescent CD8 T Effector Memory Cells are Functionally Impaired, Enriched in Aging and Disease, and a Barrier to Immunotherapy

2025-12-19

Abstract excerpt

<h4>Summary</h4> Senescent cells play important roles in various biological processes that promote fitness and health, however, their timely elimination by immune cells is critical to maintain tissue homeostasis and prevent disease. Despite this, senescent cells progressively accumulate systemically with age, suggesting that certain immune cells also become senescent and dysfunctional during aging. Supporting thi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f568fc62-7427-5dc3-87aa-0a912cbf5b3e
DOI
10.64898/2025.12.16.694716
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Senescent CD8 T Effector Memory Cells are Functionally Impaired, Enriched in Aging and Disease, and a Barrier to ImmunotherapyDOI 10.64898/2025.12.16.694716
Conclusive Identification of Senescent T Cells Reveals Their Abundance in Aging HumansSemantic proximity
Are immunosenescent T cells really senescent?Semantic proximity
Reliable Hallmarks and Biomarkers of Senescent Lymphocytes.Semantic proximity
Recent insights into the crosstalk between senescent cells and CD8 T lymphocytesSemantic proximity
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humansSemantic proximity
Epigenetic mechanisms regulating CD8+ T cell senescence in aging humansSemantic proximity
Characteristics and mechanisms of T‐cell senescence: A potential target for cancer immunotherapySemantic proximity
T Cell Replicative Senescence in Human AgingSemantic proximity
Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cellsSemantic proximity
Accumulation of SA-βGal–High Cells in Human Naïve T Cell Compartments Reveals a Stress-Adapted, Senescent-Like StateSemantic proximity
Targeting senescent cells: approaches, opportunities, challengesSemantic proximity
Immune surveillance of senescent cells in aging and diseaseSemantic proximity
Select a neighboring publication to make it the new centre.