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Article

FOXO1 constrains activation and regulates senescence in CD8 T cells

1 Jan 2021

Abstract excerpt

Naive and memory T cells are maintained in a quiescent state, yet capable of rapid response and differentiation to antigen challenge via molecular mechanisms that are not fully understood. In naive cells, the deletion of Foxo1 following thymic development results in the increased expression of multiple AP-1 family members, rendering T cells less able to respond to antigenic challenge. Similarly, in the absence of...

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PMID: 33503413
DOI: 10.1016/j.celrep.2020.108674

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