Article

Aberrant lipid accumulation and retinal pigmental epithelium dysfunction in PRCD-deficient mice

2024-03-12

Abstract excerpt

Progressive Rod-Cone Degeneration (PRCD) is an integral membrane protein found in photoreceptor outer segment (OS) disc membranes and its function remains unknown. Mutations in Prcd are implicated in Retinitis pigmentosa (RP) in humans and multiple dog breeds. PRCD-deficient models exhibit decreased levels of cholesterol in the plasma. However, potential changes in the retinal cholesterol remain unexplored. In a...

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Literature Corpus work: b6ee9e32-7247-5d18-ab02-577977b6aa3c
DOI: 10.1101/2024.03.08.584131

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