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Article

PRCD is essential for high-fidelity photoreceptor disc formation

12 Jun 2019

Abstract excerpt

Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has remained enigmatic despite multiple demonstrations that its mutations cause blindness in humans and dogs. Here, we generated a PRCD knockout mouse and observed a striking defect in disc morphogenesis, whereby newly forming discs do not...

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Share to Neuroinflammation and Neurodegeneration Mechanisms
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PMID: 31189593
DOI: 10.1073/pnas.1906421116

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