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iPSC-derived retinal pigment epithelium: an in vitro platform to reproduce key cellular phenotypes and pathophysiology of retinal degenerative diseases.

Stem cells translational medicine - 18 Mar 2025

Li Huirong, Sharma Ruchi, Bharti Kapil

Abstract excerpt

Retinal pigment epithelium (RPE) atrophy is a significant cause of human blindness worldwide, occurring in polygenic diseases such as age-related macular degeneration (AMD) and monogenic diseases such as Stargardt diseases (STGD1) and late-onset retinal degeneration (L-ORD). The patient-induced pluripotent stem cells (iPSCs)-derived RPE (iRPE) model exhibits many advantages in understanding the cellular basis of...

Topics

Humans
Retinal Pigment Epithelium
Induced Pluripotent Stem Cells
Retinal Degeneration
Phenotype
Animals
Macular Degeneration

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39729520
DOI: 10.1093/stcltm/szae097
PMCID: PMC11954503

Genes

RPE
ABCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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