Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

R17C Mutation in Photoreceptor Disc-Specific Protein, PRCD, Results in Additional Lipidation Altering Protein Stability and Subcellular Localization.

International journal of molecular sciences - 16 Sept 2022

Myers Boyden, Sechrest Emily R, Hamner Gabrielle, Motipally Sree I, Murphy Joseph, Kolandaivelu Saravanan

Abstract excerpt

Progressive rod-cone degeneration (PRCD) is a photoreceptor outer segment (OS) disc-specific protein essential for maintaining OS structures while contributing to rhodopsin packaging densities and distribution in disc membranes. Previously, we showed PRCD undergoing palmitoylation at the sole cysteine (Cys2), where a mutation linked with retinitis pigmentosa (RP) in humans and dogs demonstrates the importance of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eye Proteins

Share to Membrane Proteins

Share to Protein Stability

Share to Retinitis Pigmentosa

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 36142714
DOI: 10.3390/ijms231810802
PMCID: PMC9503786

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

R17C Mutation in Photoreceptor Disc-Specific Protein, PRCD, Results in Additional Lipidation Altering Protein Stability and Subcellular Localization.PMID 36142714Read ↗

Dual Palmitoylation of PRCD, a Photoreceptor-Specific Protein Linked to RP, Alters Protein Stability and Subcellular LocalizationSemantic proximity Read ↗

PRCD Is a Small Disc-Specific Rhodopsin-Binding Protein of Unknown Function.Semantic proximity Read ↗

The progressive rod-cone degeneration (PRCD) protein is secreted through the conventional ER/Golgi-dependent pathway.Semantic proximity Read ↗

Aberrant lipid accumulation and retinal pigmental epithelium dysfunction in PRCD-deficient miceSemantic proximity Read ↗

PRCD-associated retinitis pigmentosa in dogs and humans.Semantic proximity Read ↗

Aberrant protein trafficking in retinal degenerations: The initial phase of retinal remodeling.Semantic proximity Read ↗

RPGR: Its role in photoreceptor physiology, human disease, and future therapiesSemantic proximity Read ↗

PRCD is essential for high-fidelity photoreceptor disc formationSemantic proximity Read ↗

Palmitoylation stabilizes unliganded rod opsin.Semantic proximity Read ↗

RPGR: Role in the photoreceptor cilium, human retinal disease, and gene therapySemantic proximity Read ↗

Endoplasmic reticulum stress and rhodopsin accumulation in an organoid model of Retinitis Pigmentosa carrying a RHO pathogenic variantSemantic proximity Read ↗

The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.