Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.

Acta ophthalmologica - 1 Jun 2012

Kinnunen Kati, Petrovski Goran, Moe Morten C, Berta András, Kaarniranta Kai

Abstract excerpt

Age-related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE) and Bruch's membrane, as well as alterations in choroidal capillaries. AMD pathogenesis is strongly associated with chronic oxidative stress and inflammation that ultimately lead to protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RPE gene
Share to Lipofuscin
Share to Lysosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macular Degeneration

Share to Oxidative Stress

Share to Phenotype

Share to Retinal Pigment Epithelium

Source

Identifiers

PMID: 22112056
DOI: 10.1111/j.1755-3768.2011.02179.x

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.PMID 22112056Read ↗

Age-related macular degeneration (AMD): pathogenesis and therapy.Semantic proximity Read ↗

Pathophysiology of Age-Related Macular Degeneration: Implications for TreatmentSemantic proximity Read ↗

Mechanisms of age-related macular degeneration and therapeutic opportunities.Semantic proximity Read ↗

The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and AutophagySemantic proximity Read ↗

Molecular Crosstalk in Age-Related Macular Degeneration: Integrating Oxidative Stress, Inflammation, microRNAs, and Genetic Susceptibility Toward Precision Therapeutics.Semantic proximity Read ↗

Age-Related Macular Degeneration: Cellular and Molecular Signaling MechanismsSemantic proximity Read ↗

Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal ModelsSemantic proximity Read ↗

Autophagy regulates death of retinal pigment epithelium cells in age-related macular degenerationSemantic proximity Read ↗

Revisiting Retinal Degeneration Hallmarks: Insights from Molecular Markers and Therapy PerspectivesSemantic proximity Read ↗

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degenerationSemantic proximity Read ↗

The Dry Form of Age-Related Macular Degeneration (AMD): The Current Concepts of Pathogenesis and Prospects for Treatment.Semantic proximity Read ↗

[Atrophic age-related macular degeneration].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.