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Article

Integrative single-cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer.

Nature biotechnology - 1 Oct 2021

Wu Chi-Yun, Lau Billy T, Kim Heon Seok, Sathe Anuja, Grimes Susan M, Ji Hanlee P, Zhang Nancy R

Abstract excerpt

Cancer progression is driven by both somatic copy number aberrations (CNAs) and chromatin remodeling, yet little is known about the interplay between these two classes of events in shaping the clonal diversity of cancers. We present Alleloscope, a method for allele-specific copy number estimation that can be applied to single-cell DNA- and/or transposase-accessible chromatin-sequencing (scDNA-seq, ATAC-seq) data,...

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Identifiers

PMID: 34017141
DOI: 10.1038/s41587-021-00911-w
PMCID: PMC9127226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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