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A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immunotherapy

2023-04-21

Abstract excerpt

<title>Abstract</title> <p>Chimeric antigen receptor (CAR) T cell immunotherapy is promising for treatment of blood cancers; however, clinical benefits remain unpredictable, necessitating development of optimal CAR T cell products. Unfortunately, current preclinical evaluation platforms are inadequate due to their limited physiological relevance to humans. We herein engineered an organotypic immunocompetent chip...

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Literature Corpus work
b6ac7f5b-8702-5236-b9c5-11f46e51299b
DOI
10.21203/rs.3.rs-2762929/v1
Open publication

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A bioengineered immunocompetent human leukemia chip for preclinical screening of CAR T cell immunotherapyDOI 10.21203/rs.3.rs-2762929/v1
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