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CAR<sup>+</sup> and CAR<sup>-</sup> T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion

2022-04-02

Abstract excerpt

Chimeric antigen receptor (CAR) T cells have demonstrable efficacy in treating B-cell malignancies. Factors such as product composition, lymphodepletion and immune reconstitution are known to influence functional persistence of CAR + T cells. However, little is known about the determinants of differentiation and phenotypic plasticity of CAR + T and immune cells early post-infusion. We report single cell multi-omic...

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Literature Corpus work
d5a55fee-ad70-5360-ba15-64b20493ec07
DOI
10.1101/2022.03.29.22273013
Open publication

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CAR<sup>+</sup> and CAR<sup>-</sup> T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionDOI 10.1101/2022.03.29.22273013
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