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Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes

22 May 2025

Abstract excerpt

Chimeric Antigen Receptor (CAR) T cell therapy is a pivotal treatment for hematological malignancies. However, CAR T cell products exhibit batch-to-batch variability in cell number, quality, and in vivo efficacy due to donor-to-donor heterogeneity, and pre/post-manufacturing processes, and the manufacturing of such products necessitates careful testing, both post-manufacturing and pre-infusion. Here, we introduce...

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PMID: 40404664
DOI: 10.1038/s41467-025-59789-w

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