Article

An open CAR-T single-cell atlas to enable in-depth characterization and rational engineering of CAR-T products

2025-10-13

Abstract excerpt

<h4>BRIEF ABSTRACT</h4> We built a CAR-T cell functional atlas from over one million cells across 13 studies, integrating data from patients and healthy donors. The atlas captures 11 phenotypes, links infusion product composition with clinical response, and reveals sex- and age-dependent effects, metabolic signatures, and rare ICANS-associated cells. This open-access resource provides a foundation to understand C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 173c2d5a-0179-51a1-b48f-5472ade65cb7
DOI: 10.1101/2025.10.11.681788

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An open CAR-T single-cell atlas to enable in-depth characterization and rational engineering of CAR-T productsDOI 10.1101/2025.10.11.681788Read

CAR<sup>+</sup> and CAR<sup>-</sup> T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionSemantic proximity Read

CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionSemantic proximity Read

Deconvolution of clinical variance in CAR-T cell pharmacology and responseSemantic proximity Read

High-dimensional temporal mapping of CAR T cells reveals phenotypic and functional remodeling during manufacturing.Semantic proximity Read

Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologiesSemantic proximity Read

Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signaturesSemantic proximity Read

Integrative single-cell multi-omics of CD19-CAR <sup>pos</sup> and CAR <sup>neg</sup> T cells suggest drivers of immunotherapy response in B-cell neoplasiasSemantic proximity Read

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma PatientsSemantic proximity Read

CART-GPT: A T Cell-Informed AI Linguistic Framework for Interpreting Neurotoxicity and Therapeutic Outcomes in CAR-T TherapySemantic proximity Read

CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.Semantic proximity Read

Engineering the next generation of allogeneic CAR cells: iPSCs as a scalable and editable platformSemantic proximity Read

Single cell multiomic analysis of T cell exhaustion <i>in vitro</i>Semantic proximity Read