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CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion

2022-04-14

Abstract excerpt

<title>Abstract</title> <p>Chimeric antigen receptor (CAR) T cells have demonstrable efficacy in treating B-cell malignancies. Factors such as product composition, lymphodepletion and immune reconstitution are known to influence functional persistence of CAR+ T cells. However, little is known about the determinants of differentiation and phenotypic plasticity of CAR+ T and immune cells early post-infusion. We rep...

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Literature Corpus work
9b97945b-9422-5e52-8add-1eb6233ed465
DOI
10.21203/rs.3.rs-1495587/v1
Open publication

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CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionDOI 10.21203/rs.3.rs-1495587/v1
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