Article

Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma

2024-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Multiple myeloma (MM), a cancer of bone marrow plasma cells, is the second-most common hematological malignancy. However, despite immunotherapies like chimeric antigen receptor (CAR)-T cells, relapse is nearly universal. The bone marrow (BM) microenvironment influences how MM cells survive, proliferate, and resist treatment. Yet, it is unclear which BM niches give rise to MM pathophysiology. Her...

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Literature Corpus work: 259f214d-d3e4-50b6-8937-7c4a0ebdf921
DOI: 10.1101/2024.04.08.588601

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