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Article

Engineering chimeric antigen receptor-T cells for cancer treatment.

Molecular cancer - 15 Feb 2018

Ye Baixin, Stary Creed M, Li Xuejun, Gao Qingping, Kang Chunsheng, Xiong Xiaoxing

Abstract excerpt

Intratumor heterogeneity of tumor clones and an immunosuppressive microenvironment in cancer ecosystems contribute to inherent difficulties for tumor treatment. Recently, chimeric antigen receptor (CAR) T-cell therapy has been successfully applied in the treatment of B-cell malignancies, underscoring its great potential in antitumor therapy. However, functional challenges of CAR-T cell therapy, especially in...

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Identifiers

PMID: 29448937
DOI: 10.1186/s12943-018-0814-0
PMCID: PMC5815249

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