Article

Harnessing the Transcriptional Signatures of Car-T Cells and Leukemia/Lymphoma Using Single-Cell Sequencing Technologies

2024-01-05

Abstract excerpt

Chimeric antigen receptor (CAR) T-cell therapy has greatly improved outcomes for patients with relapsed or refractory hematological malignancies. However, challenges such as treatment resistance, relapse, and severe toxicity still hinder its widespread clinical application. Traditional transcriptome analysis has provided limited insights into the complex transcriptional landscape of both leukemia cells and enginee...

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Literature Corpus work: 8fc68294-11ed-5f38-b4e6-ccf5ec3d8e42
DOI: 10.20944/preprints202401.0451.v1

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