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Origin and dynamics of <i>Mycobacterium tuberculosis</i> subpopulations that predictably generate drug tolerance and resistance

2022-10-06

Abstract excerpt

Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting Mycobacterium tuberculosis (Mtb) population. We developed a multi-transwell robotic system to perform numerous parallel cultures of genetically barcoded Mtb exposed to steady-...

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Identifiers and source

Literature Corpus work
b687f1bd-735f-5bd6-b3ca-3f8c94fd07d5
DOI
10.1101/2022.10.05.511058
Open publication

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Origin and dynamics of <i>Mycobacterium tuberculosis</i> subpopulations that predictably generate drug tolerance and resistanceDOI 10.1101/2022.10.05.511058
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