Article

Phase variation in <i>Mycobacterium tuberculosis glpK</i> produces transiently heritable drug tolerance

2019-07-28

Abstract excerpt

The length and complexity of tuberculosis (TB) therapy, as well as the propensity of Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB control efforts. M. tuberculosis is known to have the ability to enter into a drug-tolerant state, which may explain many of these impediments to TB treatment. We have identified a novel mechanism of genetically encoded but rapidly reversible...

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Literature Corpus work: 531018c1-0238-5d6e-81ce-9c9460022ba9
DOI: 10.1101/717272

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