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Article

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

5 Sept 2019

Abstract excerpt

The length and complexity of tuberculosis (TB) therapy, as well as the propensity of Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB control efforts. M. tuberculosis is known to have the ability to enter into a drug-tolerant state, which may explain many of these impediments to TB treatment. We have identified a mechanism of genetically encoded but rapidly reversible drug...

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PMID: 31488707
DOI: 10.1073/pnas.1907631116

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