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Article

Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis.

Scientific reports - 11 Dec 2022

Kloprogge Frank, Ortiz Canseco Julio, Phee Lynette, Sadouki Zahra, Kipper Karin, Witney Adam A, Stoker Neil, McHugh Timothy D

Abstract excerpt

Concentration dependency of phenotypic and genotypic isoniazid-rifampicin resistance emergence was investigated to obtain a mechanistic understanding on how anti-mycobacterial drugs facilitate the emergence of bacterial populations that survive throughout treatment. Using static kill curve experiments, observing two evolution cycles, it was demonstrated that rifampicin resistance was the result of non-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36504241
DOI: 10.1038/s41598-022-25827-6
PMCID: PMC9742156

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