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Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia

23 May 2023

Abstract excerpt

The bone marrow (BM) is a complex microenvironment, coordinating the production of billions of blood cells every day. Despite its essential role and its relevance to hematopoietic diseases, this environment remains poorly characterized. Here we present a high-resolution characterization of the niche in health and acute myeloid leukemia (AML) by establishing a single-cell gene expression database of 339,381 BM...

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PMID: 37332612
DOI: 10.1016/j.isci.2023.106943

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