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Article

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

14 Feb 2009

Abstract excerpt

We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of LSC, we identified 3,005 differentially expressed genes. Using 2 independent analyses, we identified multiple...

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PMID: 19218430
DOI: 10.1073/pnas.0900089106

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