Article

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia

2021-12-09

Abstract excerpt

<h4>ABSTRACT</h4> The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. Here, we have studied a rare genetic disorder due to MECOM haploinsufficiency, characterized by an early-onset absence of HSCs in vivo . By generating a faithful model of this...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d9a1278-7a7a-5f70-8d19-ca2111739324
DOI: 10.1101/2021.12.09.471942

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemiaDOI 10.1101/2021.12.09.471942Read

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemiaSemantic proximity Read

Distinct gene regulatory networks govern hematopoietic and leukemia stem cellsSemantic proximity Read

Developmental stage- and site-specific transitions in lineage specification and gene regulatory networks in human hematopoietic stem and progenitor cellsSemantic proximity Read

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human developmentSemantic proximity Read

Molecular landscapes of human hematopoietic stem cells in health and leukemiaSemantic proximity Read

PHF6 suppresses self-renewal of leukemic stem cells in AMLSemantic proximity Read

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human HematopoiesisSemantic proximity Read

Single-cell multi-omics of human clonal hematopoiesis reveals that <i>DNMT3A</i> R882 mutations perturb early progenitor states through selective hypomethylationSemantic proximity Read

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cellsSemantic proximity Read

Genetic predisposition to myeloproliferative neoplasms implicates hematopoietic stem cell biologySemantic proximity Read

Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cellsSemantic proximity Read

GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicine.Semantic proximity Read