Article

Genome-scale CRISPR screening in a single mouse liver

2021-02-01

Abstract excerpt

<h4>SUMMARY</h4> A complete understanding of the genetic determinants underlying mammalian physiology and disease is limited by the availability of tools for high-throughput genetic dissection in the living organism. Genome-wide screening using CRISPR-Cas9 has emerged as a powerful method for uncovering the genetic regulation of cellular processes, but the need to stably deliver single guide RNAs to millions of c...

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Literature Corpus work: b6698cf0-c882-5489-926b-451ff37fa03d
DOI: 10.1101/2021.01.30.428976

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