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In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

31 Oct 2023

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BACKGROUND: Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens in organoids could link genetic perturbations with parallel transcriptomic readout in single cells, providing a powerful method to delineate roles of cell fate regulators. However, a big...

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PMID: 37907970
DOI: 10.1186/s13059-023-03084-8

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