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Article

In vivo functional screening for systems-level integrative cancer genomics.

Nature reviews. Cancer - 1 Oct 2020

Weber Julia, Braun Christian J, Saur Dieter, Rad Roland

Abstract excerpt

With the genetic portraits of all major human malignancies now available, we next face the challenge of characterizing the function of mutated genes, their downstream targets, interactions and molecular networks. Moreover, poorly understood at the functional level are also non-mutated but dysregulated genomes, epigenomes or transcriptomes. Breakthroughs in manipulative mouse genetics offer new opportunities to...

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PMID: 32636489
DOI: 10.1038/s41568-020-0275-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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