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Article

Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy

9 Nov 2021

Abstract excerpt

Tauopathies are a group of progressive neurodegenerative disorders characterized by the presence of insoluble intracellular tau filaments in the brain. Evidence suggests that there is a tight connection between mitochondrial dysfunction and tauopathies, including Alzheimer's disease. However, whether mitochondrial dysfunction occurs prior to the detection of tau aggregates in tauopathies remains elusive. Here, we...

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PMID: 34751671
DOI: 10.18632/aging.203683

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