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Article

Harmful R-loops are prevented via different cell cycle-specific mechanisms.

Nature communications - 22 Jul 2021

San Martin-Alonso Marta, Soler-Oliva María E, García-Rubio María, García-Muse Tatiana, Aguilera Andrés

Abstract excerpt

Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by genome-wide analysis of conditional yeast mutants that the THO transcription complex, prevents R-loop formation in G1 and S-phase, whereas the Sen1 DNA-RNA helicase prevents them only in S-phase. Interestingly, damage accumulates asymmetrically downstream of the replication fork in sen1 cells but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34294712
DOI: 10.1038/s41467-021-24737-x
PMCID: PMC8298424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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