Article

Transcription-driven cohesin repositioning rewires chromatin loops in cellular senescence

2019-10-30

Abstract excerpt

Senescence is a phenotypic state of stable proliferative arrest, typically occurring in lineage-committed cells and triggered by various stimuli. It is generally accompanied by activation of a secretory program (senescence-associated secretory phenotype, SASP), which modulates both local (tissue microenvironment) and systemic (ageing) homeostasis 1,2 . Enhancer-promoter interactions play a key role in gene regula...

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Literature Corpus work: 77901505-9e1e-5b61-8d4b-65818a5b5751
DOI: 10.1101/823831

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