Article

Genome organizer SATB1 restrains the BACH1-cMAF axis that drives autoimmunity

2025-11-25

Abstract excerpt

The establishment of central tolerance in the thymus is governed by precise gene regulatory networks, but how disrupted chromatin architecture leads to autoimmunity is unclear. The genome organizer SATB1 is essential for T cell development and its loss triggers a severe autoimmune phenotype. Here, we identify a pathogenic transcriptional axis, involving BACH1 and cMAF, that is unleashed upon SATB1 deletion. Using...

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Literature Corpus work: 3f9936f2-dd22-5078-a6d1-1b2b61d8f92d
DOI: 10.1101/2025.11.25.690242

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