Article

Overactive STAT3 drives accumulation of disease-associated CD21 <sup>low</sup> B cells

2021-12-21

Abstract excerpt

<h4>SUMMARY</h4> Dysregulated STAT3 signalling is correlated with antibody-mediated autoimmunity and B- cell neoplasia, but its effect on B cells is underexplored. Here we address this in children with STAT3 gain-of-function (GOF) syndrome and in mice with STAT3 T716M , the most common STAT3 GOF syndrome human mutation, or STAT3 K658N , a dimerization interface mutation responsible for STAT3 GOF syndrome in two...

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Literature Corpus work: ce9ea1c5-2a32-522a-bbb8-668e04da1ff4
DOI: 10.1101/2021.12.20.473595

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