Article

Satb1 integrates cohesin mediated genome organization and transcriptional regulation during T cell development

2025-06-20

Abstract excerpt

Three-dimensional (3D) genome folding, which is highly cell type-specific, plays a crucial role in orchestrating spatiotemporal gene expression. Although factors such as CTCF have been extensively studied in the hierarchical regulation of 3D chromatin organization, the mechanisms driving dynamic genome folding during T cell fate transitions remain incompletely defined. In this study, we reveal that Satb1, a chroma...

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Literature Corpus work: fb8518ba-6600-56cb-bd54-f9c041976269
DOI: 10.1101/2025.06.19.657327

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