Article

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

2022-09-07

Abstract excerpt

SATB1 (Special A-T rich Binding protein 1) is a cell type specific factor involved in chromatin remodelling events that participate in the regulation of the genetic network in developing T cells and neurons. In T cells, SATB1 is a key factor required for lineage commitment, VDJ recombination, development and maturation. In B cells, SATB1 is described as binding to the MARs-Eµ regions of the IgH locus. Considerin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ec0cc80-08f1-570b-aedf-269c21a096cd
DOI: 10.1101/2022.09.06.506747

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cellsDOI 10.1101/2022.09.06.506747Read

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cellsSemantic proximity Read

Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expressionSemantic proximity Read

Divergent SATB 1 expression across human life span and tissue compartmentsSemantic proximity Read

SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiationSemantic proximity Read

An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region.Semantic proximity Read

Genome-Wide Identification of Target Genes for the Key B Cell Transcription Factor Ets1Semantic proximity Read

Genome organizer SATB1 restrains the BACH1-cMAF axis that drives autoimmunitySemantic proximity Read

Tetramerization of SATB1 is essential for regulating of gene expression.Semantic proximity Read

SATB1 collaborates with loss of p16 in cellular transformation.Semantic proximity Read

Satb1 integrates cohesin mediated genome organization and transcriptional regulation during T cell developmentSemantic proximity Read

Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cellsSemantic proximity Read

SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.Semantic proximity Read