Article

Multimodal analysis of <i>in vitro</i> hematopoiesis reveals blood cell-specific genetic impacts on complex disease traits

2025-05-27

Abstract excerpt

In vitro hematopoiesis systems can be used to define mechanisms for blood cell formation and function, produce cell therapeutics, and model blood cell contributions to systemic disease. Hematopoietic progenitor cell (HPC) production remains inefficient, precluded by knowledge gaps related to specification and morphogenesis of specialized hemogenic endothelial cells, which undergo an endothelial-to-hematopoietic t...

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Literature Corpus work: b5e028f5-a709-5e69-8fe4-287bc77ae576
DOI: 10.1101/2025.05.23.655825

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