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Article

Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition

1 Apr 2017

Abstract excerpt

During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34 + cells. The resulting transcriptional hierarchy showed a continuum of endothelial and hematopoietic signatures. At the interface of these two...

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PMID: 28380349
DOI: 10.1016/j.celrep.2017.03.023

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