Article

Direct induction of hemogenic endothelial progenitors from hPSCs by defined factors revealed by single-cell transcriptome analysis

2021-03-19

Abstract excerpt

Transcription factors (TFs) play critical roles in stem cell maintenance and differentiation. Using single cell RNA sequencing, we investigated TFs expressed in hemogenic endothelial (HE) progenitors differentiated from human pluripotent stem cells (hPSCs) and identified upregulated expression of SOXF factors SOX7, SOX17 , and SOX18 in the HE population. To test whether overexpression of these factors increases...

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Literature Corpus work: 88b245e1-4c5c-52ea-a7b5-d69201da1f22
DOI: 10.1101/2021.03.18.435636

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