Article

PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons

2022-01-24

Abstract excerpt

How neurons in the CNS can maintain cellular identity over an entire lifespan remains largely unknown. Here we show that long-term maintenance of identity in differentiated dopaminergic and serotonergic neurons is critically reliant on the Polycomb repressive complex 2 (PRC2). Deletion of the obligate PRC2-component, Eed , in these neurons, resulted in global loss of H3K27me3, followed by a gradual activation of...

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Literature Corpus work: b54123c9-e7a0-5e6e-afa0-2c9afd288537
DOI: 10.1101/2022.01.24.477226

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