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Article

Selective requirement for polycomb repressor complex 2 in the generation of specific hypothalamic neuronal subtypes.

Development (Cambridge, England) - 1 Mar 2022

Yaghmaeian Salmani Behzad, Balderson Brad, Bauer Susanne, Ekman Helen, Starkenberg Annika, Perlmann Thomas, Piper Michael, Bodén Mikael, Thor Stefan

Abstract excerpt

The hypothalamus displays staggering cellular diversity, chiefly established during embryogenesis by the interplay of several signalling pathways and a battery of transcription factors. However, the contribution of epigenetic cues to hypothalamus development remains unclear. We mutated the polycomb repressor complex 2 gene Eed in the developing mouse hypothalamus, which resulted in the loss of H3K27me3, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35245348
DOI: 10.1242/dev.200076
PMCID: PMC8959139

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